Bioenergetic Engineering
Genetic engineering now lets us control life’s information, yet the engineering of life’s energy remains underdeveloped. A powerful set of new tools could bridge the gap, enabling breakthroughs ranging from treatments for neurodegenerative disease to biohybrid solutions for environmental remediation and resilience.
Beliefs The core beliefs that underpin the Programmable Physiology opportunity space: 1 | The hardest health challenges are not failures of single biological components, but of interacting systems → the next frontier in health is controlling complex physiological states. 2 | Modern medicine has largely learned to drug individual targets, not steer systems → programmable physiology requires matching the sophistication of our interventions to the complexity of human biology, moving from single-node perturbations to combinatorial, state-shifting control. 3 | We can't steer what we can't…
saved by
related reading
- Why Don’t Billionaires Invest In Longevity?nfx.com
- Why is progress in biology so slow?sam-rodriques.com
- Levers for Biological Progress - by Niko McCartyasimov.press
- The Goals of Neurotechnologymilan.cvitkovic.net
- Rebuild Biotech for the AI Era | Benchlingbenchling.com
- 16 Open Problems in Engineering Biology | Andreessen Horowitza16z.com
- Self-driving laboratories to autonomously navigate the protein fitness landscapenature.com
- A Future History of Biomedical Progress | Markov Biomarkov.bio
- A Future History of Biomedical Progress | Markov Biomarkovbio.github.io
- Synbio25 - A man thinks about building biologysynbio25.com
- The closed-loop manifestojakefeala.substack.com
- PENG | DARPAdarpa.mil