The closed-loop manifesto - by Jake Feala - The Loop
jakefeala.substack.com · 4,753 words · saved by 1 readers
On AI-guided optimization in biology and medicine
This started as a short blog post but I’m on break and in a transition right now, so I figured there was no better time to write a sprawling manifesto 🤷. Skip to the end for an AI summary if it’s too long (it’s quite long!). If there’s one mental model that underlies my worldview, drives my politics, and will steer decisions for any company I join, create, or invest in for least the next decade, it’s this: in our complex world, understanding is overrated, and we undervalue rapid, iterative feedback loops with reality. It’s a thesis about meeting our complex systems where they are. It’s…
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