PENG | DARPA
The Protein ENGineering (PENG) program aims to transition proteome engineering from a collection of isolated, target-specific tools into a universal, programmable discipline.
Proteins are the fundamental execution engines of biology, driving critical functions across agriculture, biotechnology, advanced materials, and environmental sustainability. As the demand for biological resilience and novel bio-manufacturing grows, there is an urgent need to engineer these molecules to operate in entirely new ways. However, current protein engineering is severely constrained by biophysical bottlenecks. Researchers face intractable limits in modifying existing proteins, including the inability to precisely target mature, 3D-folded proteins, a reliance on bespoke chemistry…
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