The under-appreciation of CHIP - by Eric Topol

It's time to drop the "indeterminate" and get serious about this biomarker

News and Analyses The under-appreciation of CHIP It's time to drop the "indeterminate" and get serious about this biomarker Eric Topol May 21, 2023 20 10 Share Each day the 50,000 to 200,000 blood stem cells in our bone marrow, known as hematopoietic (HSC), produce billions of specialized blood cells—red blood cells, platelets, B and T lymphocytes, and various myeloid cells (white blood cells, such as neutrophils and monocytes). As we age, the repeated cell divisions of the HSCs lead to acquired (“somatic”) mutations. When such a mutation of an HSC leads to a clone that expands—which denotes s

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