ON–OFF nanopores for optical control of transmembrane ionic communication | Nature Nanotechnology

Here the authors present photo-nanopores in which α-haemolysin monomers are modified with arylazopyrazoles, allowing quantitative photoswitching of the transmembrane ionic current, analogous to electronic diodes and light-tunable resistors in response to light.

Download PDF Subjects Nanopores Photochemistry Abstract Nanoscale photoswitchable proteins could facilitate precise spatiotemporal control of transmembrane communication and support studies in synthetic biology, neuroscience and bioelectronics. Here, through covalent modification of the α-haemolysin protein pore with arylazopyrazole photoswitches, we produced ‘photopores’ that transition between iontronic resistor and diode modes in response to irradiation at orthogonal wavelengths. In the diode mode, a low-leak OFF-state nanopore exhibits a reversible increase in unitary conductance of more t

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