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Clinical manifestations and diagnosis of psoriatic arthritis - UpToDate

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Clinical manifestations and diagnosis of psoriatic arthritis INTRODUCTION Psoriatic arthritis (PsA) is an inflammatory musculoskeletal disease associated with psoriasis [1] that was initially considered a variant of rheumatoid arthritis, but subsequently emerged as a distinct clinical entity [2]. Historically, seronegativity for rheumatoid factor (RF) was required for the diagnosis; however, over 10 percent of patients with uncomplicated psoriasis and up to 15 percent of the normal population have RF present in their serum. Several reports also documented positive cyclic citrullinated…

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