Hypochlorous Acid: Applications in Dermatology | Published in Journal of Integrative Dermatology
Hypochlorous acid (HClO) is a weak acid and powerful oxidant traditionally used as an active ingredient in various sanitizers and disinfectants. HClO is produced endogenously from activated leukocytes, and it was first exogenously synthesized in 1834, later to be used medicinally as a wound disinfectant during World War I and II. In this review, we aim to review the literature assessing the efficacy and safety of dermatologic uses of topical hypochlorous acid. A PubMed search for articles with the following keywords was performed: “hypochlorous acid” AND “dermatology” OR “dermis” OR “dermal.” Forty-one reports were included in the efficacy and safety analysis. Hypochlorous acid exhibits antimicrobial properties and has been demonstrated to promote re-epithelialization in wound healing with low cytotoxicity to keratinocytes and fibroblasts. Recent work has highlighted its anti-inflammatory properties via modulation of the NF-kβ signaling pathway and downregulation of inflammatory cytoki
Hypochlorous Acid: Applications in Dermatology: Dermatologic applications of hypochlorous acid are reviewed, including infection prevention, wound care, scar management, inflammatory modulation, and treatment of atopic dermatitis and pruritus. | Journal of Integrative Dermatology Journal of Integrative Dermatology Articles ▼ Perspective, Opinion, Commentary Concise Communication Book Review Case Study/Case Series Original Research Review Article All Issues About Us ▼ About For Authors Editorial Board Call for Submission Join our Mailing List Contact us Submit Manuscript Get our E-Alerts Missio
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