Diverse autism genes derail common developmental pathways | The Transmitter: Neuroscience News and Perspectives

Multiple genetic mouse models initially show delayed cortical development, but their molecular trajectories soon diverge, a new study finds.

Many genes linked to autism disrupt the same developmental pathways during embryonic development and the first two weeks of life, according to a new study in mice. As the animals mature, those shared changes give way to more gene-specific phenotypes, suggesting that the underlying pathways shift over time. Different autism mouse models showed similar developmental changes, including delayed differentiation of neural stem cells during prenatal development and altered neuronal excitability one week after birth, the study found. By 2 weeks of age, however, the overlap among the models declines…

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• Yusha Dulkina

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