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Hahn Lab at the University of North Carolina Chapel Hill

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Cells are not like machines with a computer chip “brain” that integrates inputs and controls moving parts. They are more like transformer toys, where all parts can undergo extensive rearrangement to perform vastly different functions. The only way to understand such dynamic behavior is to study molecular actions inside living cells. Our lab focuses on two synergistic areas: 1) developing methods to visualize and control protein activity in live cells and animals, and 2) applying these to address basic questions re spatio-temporal control of signaling. Our biological studies center on the integration of cytoskeletal and adhesion dynamics, and phagocytosis as a model of signaling driven by mechanical force. We are extending our studies to examine the cancer microenvironment in 3D models and in vivo. While addressing specific molecules for our biological studies, we produce generally applicable approaches to molecular imaging tools. These include new fluorescent biosensor designs to visua

Hahn Lab at the University of North Carolina Chapel Hill --> hahn lab home | people | publications | tools | cell cinema | contact | intranet --> join us research Click for Lab News iPalm of frustrated phagocytosis Ana Nogueira, Shiqiong Hu, Hahn lab Jesse Aaron, Leong Chew, AIC Janelia Cells are not like machines with a computer chip "brain" that integrates inputs and controls moving parts. They are more like transformer toys, where all parts can undergo extensive rearrangement to perform vastly different functions. The only way to understand such dynamic behavior is to study molecular action

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