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Our research moves fast and our interests change quickly. So, see our pre-prints and publications page for a list of our most recent completed projects. As an independent Fellow at The Rockefeller University, I made a transition from theoretical physics to the intersection of biology and physics. Using theory and experiments, we answered the following questions: In budding yeast, we found that two key parts of the cell cycle, periodic phosphorylation-degradation and transcription, are both under the control of the same CDK-APC/C oscillator. This result had been the subject of controversy previously. The number of oscillators makes a difference for establishing synchrony in wild-type cycles, for checkpoint arrest, and for artificially induced cell cycle arrest. We also found that a few genes constitute exceptions to this rule; they oscillate when the CDK-APC/C oscillator is blocked. Based on a mathematical analysis, we showed experimentally that one of these genes (SIC1) helps cell cycl

1. Timing of Cellular Decisions Cellular checkpoints prevent the propagation of errors, yet these safeguards are often overridden. We are advancing the quantitative study of checkpoint override , showing that it can represent an adaptive, fitness-enhancing strategy — rather than the ‘failure’ of the surveillance system. Using mathematics, novel biosensors, and dynamic perturbations, we are uncovering the principles and mechanisms by which cells balance competing demands of repair and proliferation. 2. Directed Evolution, AI- and Physics-based Design of Computational Protein F

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