Michael Domarkas

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on the atlas · 53

highlights · 72

Tony Fadell was hired to create the iPod in late January 2001. Steve Jobs greenlit the project in March 2001. They hired a contract manufacturer in April 2001, announced the product in October 2001, and shipped the first production iPod to customers in November 2001, around 290 days after getting started
Fast · Patrick Collison
Our validation results with computational functional prediction tools (such as, Pfam, ProTrek and CLEAN) suggest that they can serve as effective filters for identifying potentially concerning Raygun-generated sequences.
Miniaturizing and modifying natural proteins with Raygun | Nature
The source code and documentation of Raygun, including the latest pre-trained checkpoints and reproducibility notebooks, are available at GitHub (https://github.com/rohitsinghlab/raygun).
Miniaturizing and modifying natural proteins with Raygun | Nature
Accidentally did ketamine at a Jane Remover show
Accidentally did ketamine at a Jane Remover show. - YouTube
The first round tested 201 submissions, with only 5 (2.5%) showing significant binding, establishing a demanding baseline. We participated in the second round, which was organized following these disappointing results.
Miniaturizing and modifying natural proteins with Raygun | Nature
Designing and building an exploratory 1-2 MW mock SL5 datacenter: a real test range for the SL5 Standard, AI705, and SenL before a production facility has to carry the learning curve.
Project MoAT - Mock SL5 Datacenter Build
Fine-tuning does not diminish diversity: we verified this by generating candidates from 100 sequence-diverse human and mouse proteins using both baseline and fine-tuned models, and across varying noise levels, both versions produced comparable sequence diversity.
Miniaturizing and modifying natural proteins with Raygun | Nature
represent each protein as a probability distribution in fixed dimensions, rather than a sequence of points in high-dimensional space
Miniaturizing and modifying natural proteins with Raygun | Nature
good organoid paper treats you kindly, softly. It knows it has hurt you in the past. It must regain your trust. It walks on eggshells around you, tiptoeing around as it explains itself, where it’s been, where it plans to go, cooing away your anxieties each time they arise. In the end, you and it embrace, the organoid promising to never wound you again, and you tearfully admitting that it will, that that is its nature, but you are happy it is trying to do better
Why haven't organoids solved all of drug discovery?
There's a scene where Dr. Banks here is criticized for moving too slowly—for starting with such basic words instead of jumping to ask the question those around her pragmatically care about: "What is your purpose on Earth?"
What is the purpose of interpretability?
Darwin spent years observing the diversity of life and reflecting on those observations. Imagine telling him to "time-box his curiosity" to two weeks.
What is the purpose of interpretability?
Later, these PUFA metabolites were classified together and termed specialized pro-resolving mediators (i.e. SPM).
Specialized pro-resolving mediators
specialized proresolving mediators (SPMs) class of metabolites that function to resolve diverse inflammatory reactions and diseases in animal models and, it is proposed, in humans
TRPA1
TRPA1 can be considered to be one of the most promiscuous TRP ion channels
TRPA1
suggested as the antinociceptive mechanism for paracetamol
TRPA1
A missense mutation of TRPA1 was found to be the cause of a hereditary episodic pain syndrome. A family from Colombia suffers from debilitating upper-body pain starting in infancy that is usually triggered by fasting or fatigue (illness, cold temperature, and physical exertion being contributory factors).
TRPA1
Demonstration of generic problem-solving capabilities of the GCML
Neural sampling from cognitive maps enables goal-directed imagination and planning | Nature Machine Intelligence
Sampling from learnt cognitive maps for abstract concept spaces enables generic problem-solving through goal-directed imagination
Neural sampling from cognitive maps enables goal-directed imagination and planning | Nature Machine Intelligence
our mission is to help make AGI go well
AI 2040: Plan A — LessWrong
“just jumping to the top of your inbox”
A guide to working with clients – The Creative Independent
And death shall have no dominion
'And Death shall have no Dominion' - Dylan Thomas
He rarely attended classes; he self-studied most subjects. My guess is that he felt the professors’ pace was too slow and a waste of time, and that self-studying was faster. The downside was that he missed out on the professor “highlighting key points
What kind of person is DeepSeek's founder, Liang Wenfeng?
“Highlighting key points” (划重点, huà zhòngdiǎn): A common practice where professors tell students exactly which topics will be on an exam, enabling effective cramming
What kind of person is DeepSeek's founder, Liang Wenfeng?
is a prime example of “Be Yourself” among Chinese university students
What kind of person is DeepSeek's founder, Liang Wenfeng?
Any one of the electronic systems he built as an undergraduate would have been more than sufficient12 as a master’s thesis in electrical engineering
What kind of person is DeepSeek's founder, Liang Wenfeng?
Liang Wenfeng cycled through several provinces in East China by himself. Apparently, he often just found a place in the wild to sleep on the ground10 at night
What kind of person is DeepSeek's founder, Liang Wenfeng?
the brain actually consumes around 70% of the total hepatic glucose output.
Cerebral metabolic demand | Deranged Physiology
A full agonist has an α-value of 1.0
Receptor theory of drug action | Deranged Physiology
This is analogous to how differential geometry is only “allowed” to study concepts and perform operations that are preserved with respect to coordinate change
254A, Notes 0: A review of probability theory | What's new
Stanford University Dining Meal (Beans, Chicken, Rice, Cauliflower) 3,724.3% BPA
Report — PlasticList
used to prevent division by 0
Stochastic gradient descent - Wikipedia
where ϵ {\displaystyle \epsilon } is a small scalar (e.g. 10 − 8 {\displaystyle 10^{-8}}) used to prevent division by 0
Stochastic gradient descent - Wikipedia
where ϵ {\displaystyle \epsilon } is a small scalar (e.g. 10 − 8 {\displaystyle 10^{-8}}) used to prevent division by 0
Stochastic gradient descent - Wikipedia
where ϵ {\displaystyle \epsilon } is a small scalar (e.g. 10 − 8 {\displaystyle 10^{-8}}) used to prevent division by 0
Stochastic gradient descent - Wikipedia
if you start out trying to find a cure for diabetes you’re unlikely to end up working on a payroll SaaS company
puzzles - Nabeel S. Qureshi
present-vincent is easily the most competent version of vincent that has ever existed
YOU CAN GET WHAT YOU WANT OR YOU CAN JUST GET OLD
i know that i can do anything if i put my mind to it, i just need to figure out what exactly that thing is
YOU CAN GET WHAT YOU WANT OR YOU CAN JUST GET OLD
Every actually interesting book out there is, in some nebulous way, unobamable
Against lists of books - by Sam Kriss - Numb at the Lodge
Lives are nigh invaluable, but you have to treat them as if they're worth only a few thousand dollars
The value of a life
There may well come a day when humanity would tear apart a thousand suns in order to prevent a single untimely death
The value of a life
Reject the dichotomy. Keep your eye on the preference curve. And remember that the preference curve says this, and only this: Succeed, with no wasted motion.
Half-assing it with everything you've got
requiring an explicit call to clone() for types like String so we know we're paying the cost of a deep copy
Moves - Rust: A Better C++ Than C++
mutant p53 protein has a half-life in cells that is four to 20 times longer than the wild-type version
Restoring guardianship of the genome: Anticancer drug strategies to reverse oncogenic mutant p53 misfolding - ScienceDirect
such as using scaffolds for drug delivery
3D bioprinting of cells, tissues and organs | Scientific Reports
Similarly, Sriphutkiat et al. used acoustic excitation to align skeletal myoblast cells (C2C12) and human umbilical vein endothelial cells (HUVECs) encapsulated in methacrylated gelatin (GelMA) bioink
3D bioprinting of cells, tissues and organs | Scientific Reports
The Bay Area, including Silicon Valley and San Francisco (population 7.5 million), for example, has played host to more tech start-ups growing to valuations of more than $1 billion than the entirety of Europe (population 750 million) put together
The housing theory of everything - Works in Progress
to deal with uncertainty while profiting from the programming languages' expressiveness to encode complexity
Bayesian programming - Wikipedia
a threshold based on the cost of false positives
Against NHST — LessWrong
"blind tradition" is an expensive-to-move Schelling point in a very complex system
Against NHST — LessWrong
Plenty of otherwise-good science is done based on poor statistics
Against NHST — LessWrong