Specialized pro-resolving mediators
Specialized pro-resolving mediators (SPM, also spelled specialized proresolving mediators) are a large and growing class of cell signaling molecules formed in cells by the metabolism of polyunsaturated fatty acids (PUFA) by one or a combination of lipoxygenase, cyclooxygenase, and cytochrome P450 monooxygenase enzymes. Pre-clinical studies, primarily in animal models and human tissues, implicate SPM in orchestrating the resolution of inflammation. Prominent members include the resolvins and protectins.
Specialized pro-resolving mediators - Wikipedia Jump to content From Wikipedia, the free encyclopedia Cellular molecules that help resolve inflammation This article may be too technical for most readers to understand . Please help improve it to make it understandable to non-experts , without removing the technical details. ( March 2022 ) ( Learn how and when to remove this message ) Specialized pro-resolving mediators ( SPM , also spelled specialized proresolving mediators ) are a large and growing class of cell signaling molecules formed in cells by the metabolism of polyunsaturated fatty aci
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