Viraj Cz
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on the atlas · 41
- On Medici and Thiel - by Rohit - Strange Loop Canon12 savers
- Linkage disequilibrium — understanding the evolutionary past and mapping the medical future | Nature Reviews Genetics1 savers
- The Lederberg experiment - Understanding Evolution1 savers
- Gene Dosage - an overview | ScienceDirect Topics1 savers
- How to find focus | thesephist.com10 savers
- Requests for Startups27 savers
- what is substrate‐independence in philosophy? - Google Search1 savers
- Introduction to deep learning - AI for dummies (2/4) - Deepomatic - Visual Automation Platform1 savers
- prokaryotes and eukaryotes - Google Search1 savers
- Metabolism1 savers
- enzymes meaning - Google Search1 savers
- cytoplasm - Google Search1 savers
- Homeostasis - Google Search1 savers
- eukaryotes vs prokaryotes - Google Search1 savers
- Peter Thiel Says, 'Crypto Is Libertarian, A.I. Is Communist.' What the Heck Does That Mean? | Inc.com1 savers
- You don’t need to work on hard problems51 savers
- Reference class problem2 savers
- Reference Class Forecasting - Definition and examples — Conceptually1 savers
- Computer Networks From Scratch1 savers
- How to create money - by Rohit - Strange Loop Canon1 savers
- Math's Fundamental Flaw - YouTube1 savers
- Why I Am Not a Christian by Bertrand Russell (1927) - YouTube1 savers
- Elicit | The AI Research Assistant7 savers
- How I became a machine learning practitioner17 savers
- On being busy5 savers
- THE MIND - 1 - YouTube1 savers
- Your First Machine Learning Model | Kaggle1 savers
- The mystery of the miracle year - by Dwarkesh Patel10 savers
- How Models Work | Kaggle1 savers
- My path to OpenAI16 savers
- Curius / Onboarding2704 savers
- What Should You Do with Your Life? Directions and Advice - Alexey Guzey75 savers
- Don't Call Yourself A Programmer, And Other Career Advice | Kalzumeus Software38 savers
- Dynamicland28 savers
- Visual Information Theory -- colah's blog24 savers
- Home - colah's blog12 savers
- Textbooks as a preventative for depression - by Kasra10 savers
- Nick Bostrom's Home Page8 savers
- Rhizome Proposal8 savers
- jsomers.net | I should have loved biology7 savers
- Neural networks and deep learning6 savers
highlights · 182
LD means simply a nonrandom association of alleles at two or more loci, and detecting LD does not ensure either linkage or a lack of equilibrium.
Linkage disequilibrium — understanding the evolutionary past and mapping the medical future | Nature Reviews GeneticsBasically, the OSKM system is delivered to mice embryonic stem cells, and these cells are injected into mice blastocysts to establish a mouse line that can produce reprogrammable mice.
Partial reprogramming deep dive: the good, bad, and partially unresolved — Ada NguyenWe can therefore hijack this capability to deliver the genes we want by packaging the OSKM system into viral vectors then injecting them into the cells or animals.
Partial reprogramming deep dive: the good, bad, and partially unresolved — Ada Nguyenviruses introduce their genetic material into host cells.
Partial reprogramming deep dive: the good, bad, and partially unresolved — Ada Nguyenyou want to do it just right so that the cell is rejuvenated without being dedifferentiated)
Partial reprogramming deep dive: the good, bad, and partially unresolved — Ada NguyenThe longer you give dox to the cell or animal, the more OSKM is expressed.
Partial reprogramming deep dive: the good, bad, and partially unresolved — Ada NguyenThe activator, which is activated by doxycycline (dox), an antibiotic
Partial reprogramming deep dive: the good, bad, and partially unresolved — Ada NguyenOSKM, which is controlled by a promoter
Partial reprogramming deep dive: the good, bad, and partially unresolved — Ada Nguyenbroad enough to capture the company’s mission without constraining themselves to particular techniques or pathways.
Partial reprogramming deep dive: the good, bad, and partially unresolved — Ada NguyenRejuvenation programming: a new term invented by Altos Labs
Partial reprogramming deep dive: the good, bad, and partially unresolved — Ada NguyenIn the context of aging, epigenetic reprogramming refers to rejuvenation treatments that changes the epigenome.
Partial reprogramming deep dive: the good, bad, and partially unresolved — Ada Nguyenchange gene expression without changing the DNA sequence itself.
Partial reprogramming deep dive: the good, bad, and partially unresolved — Ada Nguyentransient reprogramming)
Partial reprogramming deep dive: the good, bad, and partially unresolved — Ada Nguyenpartial reprogramming
Partial reprogramming deep dive: the good, bad, and partially unresolved — Ada NguyenThe catch is that dedifferentiation causes cancer
Partial reprogramming deep dive: the good, bad, and partially unresolved — Ada Nguyeninduced pluripotent stem cells (iPSCs)
Partial reprogramming deep dive: the good, bad, and partially unresolved — Ada Nguyenfour transcription factors (Oct4, Sox2, Klf4, C-Myc), aka OSKM factors
Partial reprogramming deep dive: the good, bad, and partially unresolved — Ada NguyenSo the penicillin-resistant bacteria were there in the population before they encountered penicillin. They did not evolve resistance in response to exposure to the antibiotic.
The Lederberg experiment - Understanding EvolutionThe answer is no: When the original plate is washed with penicillin, the same colonies (those in position X and Y) live — even though these colonies on the original plate have never encountered penicillin before.
The Lederberg experiment - Understanding EvolutionOpen the unopened doors.
How to find focus | thesephist.comFocus is a destination, not a path.
How to find focus | thesephist.comThese cycles of divergence and convergence come from the heart, not from circumstance.
How to find focus | thesephist.comWe grow fastest not by converging constantly onto some single point set from the start, but over cycles of divergence and convergence that come and go like seasons.
How to find focus | thesephist.comAt any moment, we are either in a divergent phase of life, or in a convergent phase.
How to find focus | thesephist.comParadoxically, this means attaining focus requires us to become less focused for a little bit, exploring our options enough to develop some conviction around what’s important or what feels right.
How to find focus | thesephist.comConfidence doesn’t work that way – it’s earned, not found.
How to find focus | thesephist.comSubstrate-independence is a common assumption in the philosophy of mind. The idea is that mental states can supervene on any of a broad class of physical substrates. Provided a system implements the right sort of computational structures and processes, it can be associated with conscious experiences.
what is substrate‐independence in philosophy? - Google Searchidden layer(s) are the secret sauce of your network. They allow you to model complex data thanks to their nodes/neurons. They are “hidden” because the true values of their nodes are unknown in the training dataset.
Introduction to deep learning - AI for dummies (2/4) - Deepomatic - Visual Automation PlatformThe primary distinction between these two types of organisms is that eukaryotic cells have a membrane-bound nucleus and prokaryotic cells do not. The nucleus is where eukaryotes store their genetic information.
prokaryotes and eukaryotes - Google SearchThe Eighth Day of Creation: Makers of the Revolution in Biology, by Horace Freeland Judson.
jsomers.net | I should have loved biologythat in trying to acquire a reading knowledge of biology it’s almost more useful to study the methods than any individual facts.
jsomers.net | I should have loved biologyGenetically alter microorganisms to make molecular machines to spec; systematically turn off one gene at a time in a cell line and see what changes; edit the genome of a whole animal, and observe its life
jsomers.net | I should have loved biologyanother favorite book of mine, A Computer Scientist’s Guide to Cell Biology, by William W. Cohen
jsomers.net | I should have loved biologymost of them protein, which you understand by taking a close look.
jsomers.net | I should have loved biologyfull of little machines,
jsomers.net | I should have loved biologyOne of my favorite books is called The Machinery of Life, by David Goodsell.
jsomers.net | I should have loved biologyIn effect you get a snapshot of all the proteins being expressed at that moment.
jsomers.net | I should have loved biologyIn fact the great revelation of twentieth-century molecular biology was the coupling of structure to function.
jsomers.net | I should have loved biologyBut biology, like computing, has a bottom, and the bottom is not abstract. It’s physical. It’s shapes bumping into each other.
jsomers.net | I should have loved biologyIt’s all a big slop of global mutable state.
jsomers.net | I should have loved biologyBiology is like this, just much, much worse, because living systems aren’t intentionally designed.
jsomers.net | I should have loved biologyEverywhere you look—the compiler, the shell, the CPU, the DOM—is an abstraction hiding lifetimes of work.
jsomers.net | I should have loved biologyLearning begins with questions.
jsomers.net | I should have loved biologyand these concepts would lose their abstractness in the light of my example.
jsomers.net | I should have loved biologyThe textbooks never worked; it all only started to click when I started to do little projects for myself.
jsomers.net | I should have loved biologyEnormous subjects are best approached in thin, deep slices.
jsomers.net | I should have loved biologyMetabolism (/məˈtæbəlɪzəm/, from Greek: μεταβολή metabolē, "change") is the set of life-sustaining chemical reactions in organisms. The three main purposes of metabolism are: the conversion of the energy in food to energy available to run cellular processes; the conversion of food to building blocks for proteins, lipids, nucleic acids, and some carbohydrates; and the elimination of metabolic wastes.
MetabolismEnzymes are proteins that help speed up metabolism, or the chemical reactions in our bodies.
enzymes meaning - Google SearchCytoplasm is a thick solution that fills each cell and is enclosed by the cell membrane.
cytoplasm - Google SearchHomeostasis is any self-regulating process by which an organism tends to maintain stability while adjusting to conditions that are best for its survival.
Homeostasis - Google Search