Linkage disequilibrium — understanding the evolutionary past and mapping the medical future | Nature Reviews Genetics

Linkage disequilibrium was once a concept used little outside population genetics. However, in the genomics era it has become fundamental to our understanding of the genetic variation that is behind complex traits and evolutionary change.

Lewontin, R. C. & Kojima, K. The evolutionary dynamics of complex polymorphisms. Evolution 14, 458–472 (1960). Google Scholar Weir, B. S. Genetic Data Analysis II (Sinauer Assoc., Sunderland, Massachusetts, 1996). Google Scholar Hedrick, P. W. Genetic disequilibrium measures: proceed with caution. Genetics 117, 331–341 (1987). This paper and the reply by Lewontin (reference 33) point out many of the logical and statistical difficulties in attempting to define a 'best' LD statistic. CAS PubMed PubMed Central Google Scholar Abecasis, G. R. & Cookson, W. O. C. GOLD — Graphical Overview…

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