A subcellular map of the human kinome
An immunofluorescent analysis of 465 protein kinases revealed a substantial role of liquid-liquid phase separation in kinase localization and identified new kinase localizations to mitochondria and other organelles.
A subcellular map of the human kinome | eLife Version of Record June 3, 2021 Accepted Manuscript May 14, 2021 Download Cite Share Comment Open annotations (there are currently 0 annotations on this page). 15,985 views 1,997 downloads 78 citations Altmetric provides a collated score for online attention across various platforms and media. See more details Share this article Doi Copy to clipboard Cite this article Haitao Zhang Xiaolei Cao Mei Tang Guoxuan Zhong Yuan Si Haidong Li Feifeng Zhu Qinghua Liao Liuju Li Jianhui Zhao Jia Feng Shuaifeng Li Chenliang Wang Manuel Kaulich Fangwei Wang Liang
related reading
- Technologies to measure and modulate protein subcellular localizationnature.com
- Structural Evolution of the Protein Kinase–Like Superfamilyncbi.nlm.nih.gov
- Mnemonic portraits for 19,023 human genes — LessWronglesswrong.com
- Nobel Prize - Our Scientistsrockefeller.edu
- High-throughput measurements of protein domain functions using magnetic separation - PubMedpubmed.ncbi.nlm.nih.gov
- The ins and outs of phospholipid asymmetry in the plasma membrane: roles in health and disease - PMCncbi.nlm.nih.gov
- Biomolecular condensateen.wikipedia.org
- Identification of a mammalian H+-myo-inositol symporter expressed predominantly in the brain - PMCpmc.ncbi.nlm.nih.gov
- Publicationsbintulab.com
- Dynamic assembly of the mRNA m6A methyltransferase complex is regulated by METTL3 phase separation | PLOS Biologyjournals.plos.org
- Beyond the cytoskeleton: mesoscale assemblies and their function in spatial organization - PMCncbi.nlm.nih.gov
- Cycling of the integral membrane glycoprotein, LEP100, between plasma membrane and lysosomes: kinetic and morphological analysis - PubMedpubmed.ncbi.nlm.nih.gov