Challenges for Therapeutic Applications of Opsin-Based Optogenetic Tools in Humans
Abstract As the technological hurdles are overcome and optogenetic techniques advance to have more control over neurons, therapies based on these approaches will begin to emerge in the clinic. Here, we consider the technical challenges surrounding the transition of this breakthrough technology from an investigative tool to a true therapeutic avenue. The emerging strategies and remaining tasks sur
Abstract As the technological hurdles are overcome and optogenetic techniques advance to have more control over neurons, therapies based on these approaches will begin to emerge in the clinic. Here, we consider the technical challenges surrounding the transition of this breakthrough technology from an investigative tool to a true therapeutic avenue. The emerging strategies and remaining tasks surrounding genetically encoded molecules which respond to light as well as the vehicles required to deliver them are discussed.The use of optogenetics in humans would represent a completely new…
related reading
- Optogenetics - Wikipediaen.wikipedia.org
- All-optical electrophysiology in mammalian neurons using engineered microbial rhodopsinsnature.com
- A history of optogenetics: the development of tools for controlling brain circuits with light - PMCncbi.nlm.nih.gov
- Frontiers | Challenges for Therapeutic Applications of Opsin-Based Optogenetic Tools in Humansfrontiersin.org
- All-Optical Interrogation of Neural Circuits - PMCncbi.nlm.nih.gov
- The Goals of Neurotechnologymilan.cvitkovic.net
- CRISPR Gene Therapy: Applications, Limitations, and Implications for the Futurencbi.nlm.nih.gov
- Nanowire arrays restore vision in blind micenature.com
- A versatile, positive-going voltage indicator that enables accessible two-photon recordings in vivobiorxiv.org
- Neurotechnologies for Human Augmentationfrontiersin.org
- Optoception: perception of optogenetic brain stimulation | bioRxivbiorxiv.org
- RNA-based therapeutics: an overview and prospectusnature.com