005557 - NOD.Cg-Prkdc<scid> Il2rg<tm1Wjl>/SzJ

These mice are most often referred to using their branded name "NSG™" and are extremely immunodeficient. The mice carry two mutations on the NOD/ShiLtJ genetic background; severe combined immune deficiency (scid) and a complete null allele of the IL2 receptor common gamma chain (IL2rgnull). The scid mutation is in the DNA repair complex protein Prkdc and renders the mice B and T cell deficient. The IL2rgnull mutation prevents cytokine signaling through multiple receptors, leading to a deficiency in functional NK cells. The severe immunodeficiency allows the mice to be humanized by engraftment of human CD34+ hematopoietic stem cells (HSC), peripheral blood mononuclear cells (PBMC), patient derived xenografts (PDX), or adult stem cells and tissues. The immunodeficient NSG mice enable research in human immune function, infectious disease, diabetes, oncology, and stem cell biology. Please click here to order our Humanized Mice.

005557 - NSG Strain Details If you need help with your order, contact Customer Support For in-depth product & services help, ask our Technical Information Scientists NOD.Cg- Prkdc scid Il2rg tm1Wjl /SzJ Popular Strain # 005557 Common Name: NSG, NOD- scid IL2Rgamma null , NOD- scid IL2Rg null , NOD scid gamma Print Related Strains NOD.Cg- Prkdc scid Il2rg tm1Wjl /SzJ Overview How it's Made How it's Used Husbandry Legal Related Strains Print Contact Donate Subscribe JAX HOME CAREERS LEGAL INFORMATION RESEARCH CENTERS MOUSE GENOME INFORMATICS MOUSE PHENOME DATABASE Leading the search for TOMORROW

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