evolutionaryscale/esm

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We are releasing a world model for protein biology: a scientific engine for prediction, design, and discovery. Built on the latest generation of Evolutionary Scale Modeling (ESM), this system learns from the protein sequences produced by evolution and uses that knowledge to represent, map, predict, and design proteins across scales — from atomic interactions to evolutionary relationships spanning billions of years. The system includes three artifacts: ESMC, ESMFold2, and ESM Atlas. ESMC is a state-of-the-art protein language model that has learned the rules of protein biology from training…

saved by

• saurav kumar

related reading

• Protein World Model | Biohubbiohub.ai
• Evolutionary Scale · ESM3: Simulating 500 million years of evolution with a language modelevolutionaryscale.ai
• Language models of protein sequences at the scale of evolution enable accurate structure predictionbiorxiv.org
• Evolutionary Scale · ESM Cambrian: Revealing the mysteries of proteins with unsupervised learningevolutionaryscale.ai
• Highly accurate protein structure prediction with AlphaFoldnature.com
• Anthropic has not solved the peptide-binder design problem, but maybe bi[o]hub hasblog.genesmindsmachines.com
• AlphaFold2 @ CASP14: “It feels like one’s child has left home.” << Some Thoughts on a Mysterious Universemoalquraishi.wordpress.com
• Evo 2: DNA Foundation Model | Arc Institutearcinstitute.org
• Anthrogenanthrogen.com
• Language models of protein sequences at the scale of evolution enable accurate structure predictionbiorxiv.org
• Great expectations – the potential impacts of AlphaFold DB | EMBLembl.org
• Evo 2 Can Design Entire Genomesasimov.press