One-shot design of functional protein binders with BindCraft | Nature

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BindCraft, an open-source, automated pipeline for de novo protein binder design with experimental success rates of 10–100%, leverages AlphaFold2 weights to generate binders with nanomolar affinity without the need for high-throughput screening.

Main Proteins rarely perform their biological functions in isolation but rather rely on protein–protein interactions (PPIs) to execute complex biological processes. Designing protein binders that can specifically target and regulate PPIs therefore holds immense therapeutic and biotechnological potential. However, traditional methods for generating protein binders, such as immunization, antibody library screening or directed evolution, are often laborious, time-consuming and provide limited control over the target site. Computational protein design offers a powerful alternative, enabling…

One-shot design of functional protein binders with BindCraft | Nature

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