Glycosphingolipids - Essentials of Glycobiology - NCBI Bookshelf

Glycosphingolipids (GSLs), a subclass of glycolipids found in the cell membranes of organisms from bacteria to humans, are the major glycolipids of animals. The emphasis of this chapter is on vertebrate glycosphingolipids. Information on glycolipids of fungi, plants, and invertebrates is covered elsewhere (Chapters 20 and 23–26), as are glycosylphosphatidylinositols (GPIs), glycolipids attached to proteins as membrane anchors (Chapter 12). This chapter describes the characteristic features of GSLs, pathways for their biosynthesis, and insights into their biological roles in membrane structure, host–pathogen interactions, cell–cell recognition, and modulation of membrane protein function.

Glycosphingolipids - Essentials of Glycobiology - NCBI Bookshelf The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site. The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation Bookshelf Search database Books All Databases Assembly Biocollections BioProject BioSample Books ClinVar Conserved Domains dbGaP

related reading

• Cell-specific deletion of glucosylceramide synthase in brain leads to severe neural defects after birthpmc.ncbi.nlm.nih.gov
• Sphingolipiden.wikipedia.org
• The roles of glycosphingolipids in the proliferation and neural differentiation of mouse embryonic stem cells - PMCpmc.ncbi.nlm.nih.gov
• Lactosylceramideen.wikipedia.org
• A new brain‐penetrant glucosylceramide synthase inhibitor as potential Therapeutics for Gaucher diseasepmc.ncbi.nlm.nih.gov
• Glycosyltransferase Structure and Functionlink.springer.com
• Glycosphingolipid synthesis mediates immune evasion in KRAS-driven cancernature.com
• Reconstitution of Glucosylceramide Flip-Flop across Endoplasmic Reticulum: IMPLICATIONS FOR MECHANISM OF GLYCOSPHINGOLIPID BIOSYNTHESISpmc.ncbi.nlm.nih.gov
• Glucosylceramide flippases contribute to cellular glucosylceramide homeostasispmc.ncbi.nlm.nih.gov
• UGCG and the glycosphingolipid rheostat: a metabolic checkpoint governing immune activation and tumor immune evasion | Signal Transduction and Targeted Therapynature.com
• The Glymphatic System – A Beginner's Guidencbi.nlm.nih.gov
• Ceramide - Wikipediaen.wikipedia.org