Reconstitution of Glucosylceramide Flip-Flop across Endoplasmic Reticulum: IMPLICATIONS FOR MECHANISM OF GLYCOSPHINGOLIPID BIOSYNTHESIS - PMC

Background: Lipid flip-flop, a key feature of many glycolipid biosynthetic pathways, requires as yet unidentified flippase proteins. Results: Glucosylceramide flips slowly across protein-free vesicles but rapidly across vesicles reconstituted with ...

Background: Lipid flip-flop, a key feature of many glycolipid biosynthetic pathways, requires as yet unidentified flippase proteins. Results: Glucosylceramide flips slowly across protein-free vesicles but rapidly across vesicles reconstituted with ER membrane proteins. Conclusion: Glucosylceramide flipping is facilitated by ATP-independent ER phospholipid flippases. Significance: Defining how glucosylceramide is transported across membranes is critical for understanding the glycosphingolipid biosynthetic pathway. Keywords: Endoplasmic Reticulum (ER), Glycerophospholipid, Lipid Transport,…

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