Drosophila lipid droplets buffer the H2Av supply to protect early embryonic development - PMC

Assembly of DNA into chromatin requires a delicate balancing act, as both dearth and excess of histones severely disrupts chromatin function [1–3]. In particular, cells need to carefully control histone stoichiometry: if different types of histones ...

. Author manuscript; available in PMC: 2015 Jul 7. Published in final edited form as: Curr Biol. 2014 Jun 12;24(13):1485–1491. doi: 10.1016/j.cub.2014.05.022 Summary Assembly of DNA into chromatin requires a delicate balancing act, as both dearth and excess of histones severely disrupts chromatin function [1–3]. In particular, cells need to carefully control histone stoichiometry: if different types of histones are incorporated into chromatin in an imbalanced manner, it can lead to altered gene expression, mitotic errors, and death [4–6]. Both the balance between individual core histones…

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