Geometric constraints on human brain function | Nature

Cortical and subcortical activity can be parsimoniously understood as resulting from excitations of fundamental, resonant modes of the brain’s geometry rather than from modes of complex interregional connectivity.

Download PDF Subjects Cognitive neuroscience Computational neuroscience Abstract The anatomy of the brain necessarily constrains its function, but precisely how remains unclear. The classical and dominant paradigm in neuroscience is that neuronal dynamics are driven by interactions between discrete, functionally specialized cell populations connected by a complex array of axonal fibres 1 , 2 , 3 . However, predictions from neural field theory, an established mathematical framework for modelling large-scale brain activity 4 , 5 , 6 , suggest that the geometry of the brain may represent a more f

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