NSAIDs and Cardiovascular Risk | AAFP

GUNNAR H. GISLASON, MD, PhD, Department of Cardiology, Copenhagen University Hospital Gentofte, Gentofte, Denmark Am Fam Physician. 2009;80(12):1366-1368 See related article on page 1371. Author disclosure: Nothing to disclose. Nonsteroidal anti-inflammatory drugs (NSAIDs) have been used effectively for the treatment of pain conditions and inflammation over the past 100 years and are among the most commonly used drugs worldwide. However, during the last decade there have been increased concerns regarding the cardiovascular safety profile of NSAIDs. These concerns have primarily been related to results from studies demonstrating increased cardiovascular risk with cyclooxygenase-2 (COX-2) inhibitors. Recently, there has been accumulating evidence from several large observational studies and meta-analyses that nonselective NSAIDs are also associated with increased cardiovascular risk. The main action of NSAIDs is inhibition of the COX enzyme that facilitates synthesis of prostaglandins fr

Nonsteroidal anti-inflammatory drugs (NSAIDs) have been used effectively for the treatment of pain conditions and inflammation over the past 100 years and are among the most commonly used drugs worldwide. However, during the last decade there have been increased concerns regarding the cardiovascular safety profile of NSAIDs. These concerns have primarily been related to results from studies demonstrating increased cardiovascular risk with cyclooxygenase-2 (COX-2) inhibitors. Recently, there has been accumulating evidence from several large observational studies and meta-analyses that nonselect

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