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Hematopoietic cell transplantation (HCT) for acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) in children and adolescents - UpToDate

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Hematopoietic cell transplantation for acute myeloid leukemia and myelodysplastic syndromes in children and adolescents INTRODUCTION Allogeneic hematopoietic cell transplantation (HCT) can cure acute myeloid leukemia (AML) and myelodysplastic syndromes/neoplasms (MDS) in children, but it is associated with substantial toxicity and possible transplant-related mortality (TRM). The transplanted hematopoietic cells may recognize the recipient's cells as "foreign" and cause graft-versus-host disease (GVHD), which is a major cause of morbidity and mortality associated with allogeneic HCT.…

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