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Multiple myeloma: Overview of management - UpToDate

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INTRODUCTION Multiple myeloma (MM) is a plasma cell neoplasm characterized by clonal plasma cells that produce a monoclonal immunoglobulin. These plasma cells proliferate in the bone marrow and can result in extensive skeletal destruction with osteolytic lesions, osteopenia, and/or pathologic fractures. Additional disease-related complications include hypercalcemia, kidney impairment, anemia, and infections. This topic reviews the overall treatment strategy for patients with MM. Further details regarding the selection of initial therapy, the treatment of relapsed and/or refractory disease, and the use of hematopoietic cell transplantation are discussed separately. ● (See "Multiple myeloma: Initial treatment".) ● (See "Multiple myeloma: Treatment of first or second relapse".) ● (See "Multiple myeloma: Treatment of third or later relapse".) ● (See "Multiple myeloma: Use of hematopoietic cell transplantation".) ● (See "Multiple myeloma: Management in resource-limited settings".) ● (See "M

Multiple myeloma: Overview of management INTRODUCTION Multiple myeloma (MM) is a plasma cell neoplasm characterized by clonal plasma cells that produce a monoclonal immunoglobulin. These plasma cells proliferate in the bone marrow and can result in extensive skeletal destruction with osteolytic lesions, osteopenia, and/or pathologic fractures. Additional disease-related complications include hypercalcemia, kidney impairment, anemia, and infections. This topic reviews the overall treatment strategy for patients with MM. Further details regarding the selection of initial therapy, the…

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