Mechanism of action of diuretics - UpToDate

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INTRODUCTION Natriuretic diuretics are among the most commonly used drugs. They act by diminishing sodium reabsorption at different sites in the nephron, thereby increasing urinary sodium and water losses. A second class of diuretics, sometimes termed aquaretics, instead inhibit water reabsorption by blocking vasopressin receptors along the connecting tubule and collecting duct. The ability to induce negative fluid balance has made diuretics useful in the treatment of a variety of conditions, particularly edematous states and hypertension. A review of the mechanism and time course of action of diuretics will be presented here. Diuretic dosing and adverse effects are discussed separately: ● (See "Loop diuretics: Dosing and major side effects".) ● (See "Time course of loop and thiazide diuretic-induced electrolyte complications".) MECHANISM OF ACTION The natriuretic diuretics are generally divided into four major classes, which are distinguished by the site at which they impair sodium re

Mechanism of action of diuretics INTRODUCTION Natriuretic diuretics are among the most commonly used drugs. They act by diminishing sodium reabsorption at different sites in the nephron, thereby increasing urinary sodium and water losses. A second class of diuretics, sometimes termed aquaretics, instead inhibit water reabsorption by blocking vasopressin receptors along the connecting tubule and collecting duct. The ability to induce negative fluid balance has made diuretics useful in the treatment of a variety of conditions, particularly edematous states and hypertension. A review of the…

Mechanism of action of diuretics - UpToDate

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