Wireless closed-loop optogenetics across the entire dorsoventral spinal cord in mice | Nature Biotechnology

Optogenetics is applied to the entire mouse spinal cord.

Subjects Optogenetics Spinal cord Abstract Optoelectronic systems can exert precise control over targeted neurons and pathways throughout the brain in untethered animals, but similar technologies for the spinal cord are not well established. In the present study, we describe a system for ultrafast, wireless, closed-loop manipulation of targeted neurons and pathways across the entire dorsoventral spinal cord in untethered mice. We developed a soft stretchable carrier, integrating microscale light-emitting diodes (micro-LEDs), that conforms to the dura mater of the spinal cord. A coating of sili

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