Upstream open reading frame - Wikipedia
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Upstream open reading frame - Wikipedia Jump to content From Wikipedia, the free encyclopedia This article may be too technical for most readers to understand . Please help improve it to make it understandable to non-experts , without removing the technical details. ( October 2022 ) ( Learn how and when to remove this message ) An upstream open reading frame ( uORF ) is an open reading frame (ORF) within the 5' untranslated region (5'UTR) of an mRNA . uORFs can regulate eukaryotic gene expression . [ 1 ] [ 2 ] Translation of the uORF typically inhibits downstream expression of the primary ORF.
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