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Protein Destabilization as a Common Factor in Diverse Inherited Disorders - PubMed

pubmed.ncbi.nlm.nih.gov · 1,245 words · saved by 1 readers

Protein destabilization by amino acid substitutions is proposed to play a prominent role in widespread inherited human disorders, not just those known to involve protein misfolding and aggregation. To test this hypothesis, we computationally evaluate the effects on protein stability of all possible …

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