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Synonymous substitution - Wikipedia

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A synonymous substitution (often called a silent substitution though they are not always silent) is the evolutionary substitution of one base for another in an exon of a gene coding for a protein, such that the produced amino acid sequence is not modified. This is possible because the genetic code is "degenerate", meaning that some amino acids are coded for by more than one three-base-pair codon; since some of the codons for a given amino acid differ by just one base pair from others coding for the same amino acid, a mutation that replaces the "normal" base by one of the alternatives will result in incorporation of the same amino acid into the growing polypeptide chain when the gene is translated. Synonymous substitutions and mutations affecting noncoding DNA are often considered silent mutations; however, it is not always the case that the mutation is silent.[1][2][3][4][5]

Synonymous substitution - Wikipedia Jump to content From Wikipedia, the free encyclopedia Form of evolutionary mutation For words related to "synonym", see Synonym (disambiguation) . Point substitution mutations of a codon, classified by their impact on protein sequence A synonymous substitution (often called a silent substitution though they are not always silent) is the evolutionary substitution of one base for another in an exon of a gene coding for a protein , such that the produced amino acid sequence is not modified. This is possible because the genetic code is " degenerate ", meaning th

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