Predicting Deleterious Amino Acid Substitutions

Many missense substitutions are identified in single nucleotide polymorphism (SNP) data and large-scale random mutagenesis projects. Each amino acid substitution potentially affects protein function. We have constructed a tool that uses sequence homology ...

Genome Res . 2001 May;11(5):863–874. doi: 10.1101/gr.176601 Predicting Deleterious Amino Acid Substitutions Pauline C Ng Pauline C Ng 1 Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA; 2 Department of Bioengineering, University of Washington, Seattle, Washington 98105, USA; 3 Howard Hughes Medical Institute, Seattle, Washington 98109, USA Find articles by Pauline C Ng 1,2 , Steven Henikoff Steven Henikoff 1 Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA; 2 Department of Bioengineering, University of Washington, Seattle, Washington 98105, USA; 3 Ho

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