✳flâneur — a map of the web's best reading

Why cancer cells have a more hyperpolarised mitochondrial membrane potential and emergent prospects for therapy | bioRxiv

biorxiv.org · 20,370 words · saved by 1 readers

Cancer cells have a more hyperpolarised mitochondrial membrane potential (ΨIM) than normal cells. ΨIM = ∼−220 mV in cancer cells as compared to ∼−140 mV in normal cells. Until now it has not been known why. This paper explains this disparity, in a mathematical framework, and identifies molecular targets and operations unique to cancer cells. These are thence prospective cancer drug targets. BMS-199264 is proposed as an anti-cancer drug. It inhibits the reverse, proton-pumping mode of ATP synthase, which this paper identifies as crucial to cancer cells but not to healthy, normal adult cells. In the cancer cell model, the adenine nucleotide exchanger (ANT) is inversely orientated in the mitochondrial inner membrane as compared to normal cells. This predicts it to have a different drug interaction profile, which can be leveraged for cancer therapy. Uncouplers, which dissipate the proton motive force, are proposed as anti-cancer medicines e.g. 2,4-dinitrophenol.

Why cancer cells have a more hyperpolarised mitochondrial membrane potential and emergent prospects for therapy | bioRxiv Skip to main content New Results Why cancer cells have a more hyperpolarised mitochondrial membrane potential and emergent prospects for therapy Michael D Forrest Ph.D. doi: https://doi.org/10.1101/025197 Michael D Forrest Ph.D. Department of Computer Science, University of Warwick , Coventry, UK Find this author on Google Scholar Find this author on PubMed Search for this author on this site Abstract Full Text Info/History Metrics Preview PDF Abstract Cancer cells have a m

Explore this link on the map →

related reading