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Cancer cells educate natural killer cells to a metastasis-promoting cell state - PMC

pmc.ncbi.nlm.nih.gov · 11,150 words · saved by 1 readers

Chan et al. show that natural killer (NK) cells can be reprogrammed by breast cancer cells to promote metastasis. Reprogramming can be blocked by targeting NK cell inhibitory receptors TIGIT or KLRG1 or inhibiting DNA methyltransferases, which ...

J Cell Biol . 2020 Jul 9;219(9):e202001134. doi: 10.1083/jcb.202001134 Cancer cells educate natural killer cells to a metastasis-promoting cell state Isaac S Chan Isaac S Chan 1 Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 2 Department of Cell Biology and Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD Find articles by Isaac S Chan 1, 2, ✉ , Hildur Knútsdóttir Hildur Knútsdóttir 4 Department of Biomedical Engineering, Johns Hopkins University Whiting School of Engineering, Balt

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