Similar but different: distinct roles for KRAS and BRAF oncogenes in colorectal cancer development and therapy resistance
Colorectal cancer (CRC) is characterized by recurrent mutations deregulating key cell signaling cascades and providing the cancer cells with novel functional traits. Among the most frequent mutations in CRC are gain-of-function missense mutations in KRAS ...
Oncotarget . 2015 Jul 30;6(25):20785–20800. doi: 10.18632/oncotarget.4750 Similar but different: distinct roles for KRAS and BRAF oncogenes in colorectal cancer development and therapy resistance Markus Morkel Markus Morkel 1 Charité Universitätsmedizin Berlin, Institute of Pathology, Laboratory of Molecular Tumor Pathology and Systems Biology, Berlin 10117, Germany Find articles by Markus Morkel 1 , Pamela Riemer Pamela Riemer 1 Charité Universitätsmedizin Berlin, Institute of Pathology, Laboratory of Molecular Tumor Pathology and Systems Biology, Berlin 10117, Germany 2 DKTK, German Consorti
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