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P53

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p53, also known as tumor protein p53, TP53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory transcription factor protein that is often mutated in human cancers. The p53 proteins (originally thought to be, and often spoken of as, a single protein) are crucial in vertebrates, where they prevent cancer formation. As such, p53 has been described as "the guardian of the genome" because of its role in conserving stability by preventing genome mutation. Hence TP53 is classified as a tumor suppressor gene.

p53 - Wikipedia Jump to content From Wikipedia, the free encyclopedia Mammalian protein found in humans For other uses, see P53 (disambiguation) . TP53 Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4QO1 , 1A1U , 1AIE , 1C26 , 1DT7 , 1GZH , 1H26 , 1HS5 , 1KZY , 1MA3 , 1OLG , 1OLH , 1PES , 1PET , 1SAE , 1SAF , 1SAK , 1SAL , 1TSR , 1TUP , 1UOL , 1XQH , 1YC5 , 1YCQ , 1YCR , 1YCS , 2AC0 , 2ADY , 2AHI , 2ATA , 2B3G , 2BIM , 2BIN , 2BIO , 2BIP , 2BIQ , 2FEJ , 2FOJ , 2FOO , 2GS0 , 2H1L , 2H2D , 2H2F , 2H4F , 2H4H , 2H4J , 2H59 , 2J0Z , 2J10 , 2J11 , 2J1W , 2J1X , 2J1Y , 2J1Z

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