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Gregory Verdine Finds Ways To ‘Drug the Undruggable’ Diseases | Harvard Medical School

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Force behind pancreatic cancer progress learned improvisational thinking from a devastating family accident Chemical biologist Gregory Verdine was driving from his home north of Boston to his office in Cambridge when he had to pull over. Verdine — the Erving Professor of Chemistry in the Department of Stem Cell and Regenerative Biology and of Chemistry and Chemical Biology, Emeritus, at Harvard University and Harvard Medical School — was listening to the podcast Interesting Times with Ross Douthat. The guest was former U.S. Sen. Ben Sasse, who has stage 4 (metastatic) pancreatic cancer. Few with the diagnosis survive beyond a year. Get more HMS news Sasse sounded surprisingly upbeat as he described an experimental drug that had reduced his tumors by 76 percent and helped him beat survival expectations (though not cure him, he noted). “I did that,” Verdine recalled thinking. “I made that possible.” The drug was daraxonrasib, which garnered attention in May for its unprecedented success

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