Fcγ receptors as regulators of immune responses | Nature Reviews Immunology
The function of the various subclasses of IgG molecules is mediated by the family of Fc receptors for IgG (FcγRs). This Review outlines how FcγRs regulate immune responses and the relevance of this information to developing new therapies for treating human diseases.
Key Points The family of Fc receptors for IgG (FcγRs) is broadly expressed by cells of haematopoietic origin and consists of one inhibitory and several activating receptors that differ in their affinity and specificity for immunoglobulin subclasses. On innate immune effector cells, activating and inhibitory FcγRs set a threshold for cell activation by immune complexes. Important examples for effector responses that are regulated by FcγRs are phagocytosis, ADCC and the release of inflammatory mediators. On dendritic cells (DCs), paired FcγR expression regulates cell maturation and antigen prese
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