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Immune Regulation | People | Osaka University Immunology Frontier Research Center

ifrec.osaka-u.ac.jp · 1,406 words · saved by 1 readers

The discovery of interleukin 6 (IL-6) and elucidation of its associated receptor signaling pathway, highlighted the important role of cytokines in regulating immune cells. When cytokines become aberrantly regulated, this leads to the inappropriate activation of immune cells. In some cases, this is an important step in the development of autoimmune diseases, such as rheumatoid arthritis (activation of IL-6 signaling) and systemic lupus erythematosus (activation of type-I interferon signaling). The current challenges, and principal aims of our research, are to make advances in our understanding of the mechanisms of autoimmune disease and related cytokine signaling pathways, to ultimately improve health care- thus "from bench to bedside". Post-transcriptional regulation of IL-6 has been largely uncharacterized, with the exception of the RNase Regnase-1, which prevents autoimmunity by destabilizing IL-6 mRNA. Here, we identified a novel RNA binding protein, AT-rich interactive domain 5a (A

Immune Regulation | People | Osaka University Immunology Frontier Research Center Home People Immune Regulation Immune Regulation TEL +81-6-6879-4957 FAX +81-6-6879-4958 Overview Introduction to our Laboratory. The discovery of interleukin 6 (IL-6) and elucidation of its associated receptor signaling pathway, highlighted the important role of cytokines in regulating immune cells. When cytokines become aberrantly regulated, this leads to the inappropriate activation of immune cells. In some cases, this is an important step in the development of autoimmune diseases, such as rheumatoid arthritis

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