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Normal Liver Histology 101 | AASLD

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The outer surface of the liver is composed of a fibrous / connective tissue capsule (Figure 1). The outermost surface is covered by a thin layer of mesothelial cells that arises from the peritoneum (Figure 2). The capsule surrounds the liver parenchyma, which is composed of hepatocytes. Hepatocytes are large polygonal cells with eosinophilic (pink) cytoplasm, round nuclei, and prominent nucleoli (Figure 1). Hepatocytes are discussed in more detail in later sections. Microscopically, the organization of liver parenchyma can be represented by three different schematics: (1) the classic (hepatic) lobule, (2) the portal lobule, and (3) the hepatic acinus. Classic (hepatic) lobules are based upon blood flow. They are organized as “hexagons,” with the central vein (CV) in the center of the lobule and portal tracts (PTs) at the periphery of the lobule (corners of the hexagon) (Figures 3 and 4). The PT consists of the hepatic artery (HA), portal vein (PV), and bile duct (BD). Blood enters the

Normal Liver Histology 101 | AASLD Skip to content Core Series Pathology Pearls Normal Liver Histology 101 Normal Liver Histology 101 June 12, 2020 Phoenix Bell Share Copy Link Twitter Facebook Basic Architecture The Capsule The outer surface of the liver is composed of a fibrous / connective tissue capsule (Figure 1). The outermost surface is covered by a thin layer of mesothelial cells that arises from the peritoneum (Figure 2). The Parenchyma The capsule surrounds the liver parenchyma, which is composed of hepatocytes. Hepatocytes are large polygonal cells with eosinophilic (pink) cytoplasm

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