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Andrew Brack on X: "@ArtirKel Parabiosis would argue a large chunk is cell extrinsic. If going all in on cell intrinsic mechanisms, I would prioritize cells that make their own organs/tissues through proliferation-HSCs, and organs that are highly secretory (making the environment) like liver." / X

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To view keyboard shortcuts, press question mark View keyboard shortcuts Messages Home Explore Notifications Messages Grok Premium Lists Bookmarks Jobs Communities Verified Orgs Profile More Post Lada Nuzhna @LNuzhna Post See new posts Conversation José Luis Ricón Fernández de la Puente @ArtirKel · 12h A true rejuvenating intervention is that it is permanent (young cells don't suddenly age so if you got real rejuvenation you got it stable). As a result, rejuvenation therapies are single shot therapies (vs continuous like rapamycin which slows but does not reverse). 4 20 1.1K Andrew Brack @BrackLab · 9h But unless you are going to develop a rejuvenation therapy that targets every cell at the same time then those rejuvenated cells will be in an aged environment. And we are WAY off from rejuvenating every cell at same time. So the net effect is young cells in a sea of old cells. 1 3 119 José Luis Ricón Fernández de la Puente @ArtirKel · 9h I tend to think that a good chunk of aging is cel

@BrackLab: Parabiosis would argue a large chunk is cell extrinsic. If going all in on cell intrinsic mechanisms, I would prioritize cells that make their own organs/tissues through proliferation-HSCs, and organs that are highly secretory (making the environment) like liver.

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