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Landscape of human spinal cord cell type diversity at midgestation | bioRxiv

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Understanding spinal cord generation and assembly is essential to elucidate how motor behavior is controlled and how disorders arise. The cellular landscape of the human spinal cord remains, however, insufficiently explored. Here, we profiled the midgestation human spinal cord with single cell-resolution and discovered, even at this fetal stage, remarkable heterogeneity across and within cell types. Glia displayed diversity related to positional identity along the dorso-ventral and rostro-caudal axes, while astrocytes with specialized transcriptional programs mapped onto distinct histological domains. We discovered a surprisingly early diversification of alpha (α) and gamma (γ) motor neurons that control and modulate contraction of muscle fibers, which was suggestive of accelerated developmental timing in human spinal cord compared to rodents. Together with mapping of disease-related genes, this transcriptional profile of the developing human spinal cord opens new avenues for interroga

Landscape of human spinal cord cell type diversity at midgestation | bioRxiv Skip to main content New Results Landscape of human spinal cord cell type diversity at midgestation View ORCID Profile Jimena Andersen , View ORCID Profile Nicholas Thom , View ORCID Profile Jennifer L. Shadrach , View ORCID Profile Xiaoyu Chen , View ORCID Profile Neal D. Amin , View ORCID Profile Se-Jin Yoon , View ORCID Profile William J. Greenleaf , View ORCID Profile Fabian Müller , View ORCID Profile Anca M. Pașca , View ORCID Profile Julia A. Kaltschmidt , View ORCID Profile Sergiu Pașca doi: https://doi.org/10

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