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Research Areas - Svendsen Lab | Cedars-Sinai

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Amyotrophic lateral sclerosis (ALS or Lou Gehrig’s disease) is a devastating and lethal disease resulting in the degeneration of neurons located in the brain and spinal cord responsible for controlling muscle function. Progression from early muscle twitches to complete paralysis and death usually happens within four years. There is currently no cure for ALS and only one approved therapeutic agent, Riluzole, which has been shown to minimally slow the progress of the disease. The CIRM disease team project aims to use a powerful combined neural progenitor cell and growth factor approach to treat patients with amyotrophic lateral sclerosis. Human neural progenitor cells found early in brain development can be isolated and expanded in culture to large banks of billions of cells. When transplanted into animal models of ALS, they have been shown to mature into support cells for dying motor neurons called astrocytes. In other studies, growth factors such as glial cell line-derived growth facto

Research Areas - Svendsen Lab | Cedars-Sinai Svendsen Lab Svendsen Lab Toggle mobile sub-nav Back to Svendsen Lab Lab Members Research Areas Research Areas Translational/Regenerative Therapy Approach Disease Team CIRM Grant Progenitor Cells Secreting GDNF for the Treatment of ALS Amyotrophic lateral sclerosis (ALS or Lou Gehrig’s disease) is a devastating and lethal disease resulting in the degeneration of neurons located in the brain and spinal cord responsible for controlling muscle function. Progression from early muscle twitches to complete paralysis and death usually happens within four y

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