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PRISM | E11 Bio

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We share the PRISM platform for self-correcting neuron tracing using simple light microscopes. We describe a pilot study in mouse hippocampus and demonstrate how PRISM improves genetically labelled neuron tracing accuracy while adding molecular detail. We release a toolbox of constructs, methods, and data for research use. Mapping the brain’s wiring with today’s tools is like navigating a black-and-white subway map with millions of tracks – the ultimate tracing problem. Yet finding a solution will transform neuroscience, and is critical for curing brain disorders, building safer and human-like AI, and even simulating brain function. Today we are excited to release the full details of our PRISM neuron tracing platform – a major step towards solving this problem. The heart of PRISM is cell-filling tags (barcodes) that give each neuron a machine-readable identity, which is like adding 100,000 colors to the subway map. By combining barcodes with expansion microscopy and machine learning, P

October 1, 2025 E11 Bio Releases PRISM Technology for Self-Correcting Neuron Tracing By Andrew C. Payne, Arlo Sheridan, Kathleen G.C. Leeper, Johan Winnubst Table of Contents Problem Opportunity PRISM at a glance Key Findings Next Steps How Can I Use PRISM? Acknowledgements References Share to: X · LinkedIn · Bluesky We share the PRISM platform for self-correcting neuron tracing using simple light microscopes. We describe a pilot study in mouse hippocampus and demonstrate how PRISM improves genetically labelled neuron tracing accuracy while adding molecular detail. We release a toolbox of cons

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