flâneur

Holly Zhuang

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on the atlas — 3

highlights — 9

  • Industry, government, and academia need to do a better job of making sure that patients aren’t left behind because the right data do not exist.
    This is biology's century. We're not ready for it
  • But he’s struck that CAR-T is still not approved for adults with chronic lymphocytic leukemia, the disease he had. It turned out the treatment was less effective in CLL than some other blood cancers, and as new drugs became available conducting CLL studies became a lower priority.
    This is biology's century. We're not ready for it
  • But the bill seems to imagine the evidence of efficacy would come from real-world evidence, not randomized trials.
    This is biology's century. We're not ready for it
  • In June 2020, the study showed that hydroxychloroquine, which had been widely used on hospitalized patients during the deadly Covid outbreak in New York City, was ineffective. Two weeks later, it showed a different cheap medicine, dexamethasone, reduced deaths in patients on ventilators by 35%. The study would also show that monoclonal antibodies and the arthritis drugs baricitinib and tocilizumab reduced the death rate in hospitalized Covid patients, while convalescent plasma, aspirin, and the gout drug colchicine didn’t.
    This is biology's century. We're not ready for it
  • "Even the providers, their primary purpose is not to collect more knowledge but to implement delivery with better margins. In other words, markets work."
    This is biology's century. We're not ready for it
  • An ideal system would collect data — and perhaps even conduct randomized controlled trials of different treatments — almost automatically.
    This is biology's century. We're not ready for it
  • The core technology is not the drug molecule but randomization, randomly assigning patients to get one thing or another. This is the only way researchers can be sure that people who get the drug live longer, and the outcome is not due to chance.
    This is biology's century. We're not ready for it
  • The cholesterol drugs known as statins — atorvastatin, rosuvastatin, simvastatin — are among the most prescribed medicines in the country, and even so public health experts say more people should be taking them for their proven ability to prevent heart attacks and strokes. Years after its patent expired atorvastatin — it used to be called Lipitor — is the most used drug in America.
    This is biology's century. We're not ready for it
  • What he’s really done is he’s created this immense vertical filing cabinet in his brain of layers and layers and layers of files of information that he can draw back on now for more than 70 years worth of data.
    Curius / Onboarding