Jordan Marshall

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Notably, the new taxa contributing to the increased diversity were largely not from the fermented foods themselves, indicating an indirect effect of their consumption on remodeling the microbiota. It is unclear whether these “new” taxa were newly recruited to the microbiota from the environment or were already present but undetected and increased in relative abundance to detectable levels during the intervention.
Gut-microbiota-targeted diets modulate human immune status: Cell
These data suggest that the increase in microbiota diversity in the high-fermented-food-diet arm was not primarily due to consumed microbes but rather a result of shifts in or new acquisitions to the resident community. These data support that fermented food consumption has an indirect effect on microbiota diversity, rendering the microbiota receptive to the incorporation or increased representation of previously undetected strains within the gut.
Gut-microbiota-targeted diets modulate human immune status: Cell
Notably, although the number of servings of fermented food consumed was correlated to an increase in diversity, this relationship was not as strong as the relationship between diversity and time (Figure 5C). Participants in the high-fermented-food-diet arm consumed a variety of fermented foods, including yogurt, kefir, fermented cottage cheese, kombucha, vegetable brine drinks, and fermented vegetables, such as kimchi.
Gut-microbiota-targeted diets modulate human immune status: Cell
This diversity increase was sustained during the choice period, when fermented food intake was higher than baseline but lower than at the end of maintenance, suggesting that increased diversity likely involved gut ecosystem remodeling rather than an immediate reflection of consumed quantities.
Gut-microbiota-targeted diets modulate human immune status: Cell
Participants in the high-fermented-food diet arm consumed an average of 0.4 ± 0.6 servings per day of fermented food at baseline, which increased to an average of 6.3 ± 2.9 servings per day at the end of the maintenance phase (Figure 1D). Importantly, participants in the high-fiber-diet arm did not increase their consumption of fermented foods (Figure 1C, dashed line), nor did participants consuming the high-fermented-food diet increase their fiber intake (Figure 1D, dashed line) during the course of the study.
Gut-microbiota-targeted diets modulate human immune status: Cell
“personality” is not achieved by in-your-face choices like loud fonts or animations; instead, personality shines through when the interface allows the functionality to come through clearly. Such an interface makes the personality more about functionality than style, which is almost always better.
My Philosophy of Product Building (Part II) - Divinations - Every
less is better, move quickly and based on your intuition without overthinking it, and show the product to users to uncover problems and solve them iteratively.
My Philosophy of Product Building (Part II) - Divinations - Every
Unlike school assignments or intern projects, you get no points for seeming like you worked hard. Nobody cares. The only thing that matters is whether a user A) finds out about it, B) immediately understands why it’s useful, and C) intuitively understands how to use it. Complexity is a drag on each of these.
My Philosophy of Product Building (Part II) - Divinations - Every
Unlike school assignments or intern projects, you get no points for seeming like you worked hard. Nobody cares. The only thing that matters is whether a user A) finds out about it, B) immediately understands why it’s useful, and C) intuitively understands how to use it.
My Philosophy of Product Building - Divinations - Every
“little” project and give you unhelpful feedback on the assumption that you’re trying to raise a series A from Sequoia. For example, they might encourage you to stop building the product yourself and recruit a team. This is good advice if you want to make one valuable thing right now, but it’s bad advice if your goal is to build skills that will enable you to make many valuable things in the future.
My Philosophy of Product Building - Divinations - Every
If no one thinks you’re crazy, you’re too late: The recipe for 100x outcomes is to have everyone agree with you...later. When you first step foot into something new, if people don't consider you crazy, it probably doesn't have the 100x upside anymore. The 100x+ opportunities are a result of them being non-consensus bets. The idea of private companies being successful in space was ridiculous when Elon Musk started SpaceX. Now it's consensus. You're crazy...until you're not.
The Curiosity Chronicle | Prioritizing the Rocks, 21 Business Truths, & More
ritual apps should have a quality-over-quantity mindset that also prioritizes active over passive usage and consistency over intensity.
In the Next Era of Social, Build Rituals, Not Habits - Every
After all, rituals are a delicate balance of art and science. Something “meaningful” and “intentional” can’t be achieved with rules and rigidity. A purposeful culture, and ideally a community that reinforces this at scale, must emerge.
In the Next Era of Social, Build Rituals, Not Habits - Every
Ritual social isn’t about occupying as much time and attention as possible. It’s about having a special place in someone’s day or week— and that may well be a recipe for long-term success.
In the Next Era of Social, Build Rituals, Not Habits - Every
A collective experience can turn an otherwise private ritual into something social.
In the Next Era of Social, Build Rituals, Not Habits - Every
limiting supply can help set up a long-lasting ritual.
In the Next Era of Social, Build Rituals, Not Habits - Every
It’s a mechanic that encourages presence and participation—something core to ritual apps.
In the Next Era of Social, Build Rituals, Not Habits - Every
To create rituals, products need constraint and specificity. Constraint is about what the product allows; specificity is about what you want users to do.
In the Next Era of Social, Build Rituals, Not Habits - Every
It’s intentional. You consciously engage and are present. It’s participatory. You’re active rather than passive. It’s meaningful. It’s valuable beyond the action itself or any utility. It’s often emotional—e.g. nostalgic, fun, celebratory, identity-forming. It’s consistent. It’s reliable in timing, expectation, quality, etc. It’s finite. There’s a constraint around time, effort, or action itself.
In the Next Era of Social, Build Rituals, Not Habits - Every
Ritual social apps aim to create regular, purposeful moments, even if small ones; they’re at their best as a mindful microdose of meaning and feel-good.
In the Next Era of Social, Build Rituals, Not Habits - Every
When you also recognize that today’s problems are likely the consequence of actions taken in the past, you’ll be better able to assess them
Blinkist: Serving curious minds.
Not that he’s alone here. We all do this, all the time. We get caught up in the race. We forget that we determine where the finish line is. This is ego incarnate: the need to have – to have more power, more money, more exciting experiences – without considering whether the power, the money, the experiences will get us closer to what matters to us.
Blinkist: Serving curious minds.
Ego is stolen. Confidence is earned.
Blinkist: Serving curious minds.
What steps can you take to create more energy than you consume?
The Curiosity Chronicle | The Power Walk, Batteries Included, & More
What are the traits of a "batteries included" individual?
The Curiosity Chronicle | The Power Walk, Batteries Included, & More
Batteries Included: Come with a built in energy source. They create energy for those around them. Batteries Not Included: Come without a built in energy source. They rely on others to create energy for them.
The Curiosity Chronicle | The Power Walk, Batteries Included, & More
I recommend delineating your life into two parts: Active vs. Passive. What parts of your life require active energy and attention from you? What parts require only passive energy?
Cognitive Load | Caseinterview
We found that food restriction, resulting in a 15% reduction of body weight, led to a 29% reduction in ATP expenditure associated with excitatory postsynaptic currents, which was mediated by a decrease in single-channel AMPA receptor (AMPAR) conductance.
Neocortex saves energy by reducing coding precision during food scarcity: Neuron
positive relationship between overall sugar and sugar-sweetened beverages consumption and symptoms of ADHD
Sugar consumption, sugar sweetened beverages and Attention Deficit Hyperactivity Disorder: A systematic review and meta-analysis - ScienceDirect
"There are no strangers here; Only friends you haven't yet met." - William Butler Yeats
The Curiosity Chronicle | Life Rules Worth Breaking
internet culture is sucking more and more people in and generating more and more subcultures.
Recursive Publishing - Divinations - Every
Of course, there is a big downside to recursive systems: they output a lot of garbage. Some of it is garbage that nobody wants, but this actually isn’t a big deal. What’s worse is when recursive systems amplify content that causes real-world harm. Memes are seeds for worldviews, and worldviews drive behavior, and behavior can cause harm. In the past, linear systems minimized this downside almost automatically.
Recursive Publishing - Divinations - Every
Creating a UX where users had to decide on virtually nothing—and the app just learned from their behavior—was TikTok's monster idea in an otherwise crowded boneyard. Everything else about its product and network grew from the powerful way that it connected consumers to creators without explicit follow actions. Without this innovation, TikTok would have likely failed.
The Boneyard Principle: Why the Next Big Thing will Emerge from a Failed Idea - Every
[TikTok’s] entire screen is filled with one video. Everything you do from the moment the video begins playing is signal as to your sentiment towards that video. Do you swipe up to the next video before it has even finished playing? Did you watch it more than once, letting it loop?...Did you share the video through the built-in share pane?…The default UI of our largest social networks today is the infinite vertically scrolling feed...As you scroll up and past many stories, the algorithm can’t “see” which story your eyes rest on…if the user doesn’t press any of the feedback buttons like the Like…
The Boneyard Principle: Why the Next Big Thing will Emerge from a Failed Idea - Every
magic often hides within UX details — particularly, those that help people make fewer decisions and take fewer risks. The more opinionated an app is about how it should be used, the easier it is for users to act without fear of rejection. Products benefit from giving people the plausible deniability to say: “I’m not seeking attention, I’m just doing what this app tells me to do!”
The Boneyard Principle: Why the Next Big Thing will Emerge from a Failed Idea - Every
do it frequently and immediately, from a place of care, as a set of things you have observed, explaining the impact.
Operating Well: What I Learned at Stripe - Every
Start with a small team, especially when navigating product market fit. Larger teams create communication overhead. But more importantly they force definition = you have to divide up the work and make it clear who is responsible for what.
Operating Well: What I Learned at Stripe - Every
There is a certain amount of power in every value chain, and that power cannot be created or destroyed, it only can be transformed. The power is a reflection of who controls the important integration point, and who is providing a less-important modularized component. Therefore, if the important integration point shifts (as was the case in the Netflix example), then the layers of the value chain that used to have power will lose their power, and they must modularize and conform to what the integrator needs.
Finding Power - Divinations - Every
If you overshoot buyers’ needs, your product becomes “good enough.” This is a dangerous situation, because the basis of competition could change, and the important integration you controlled could become less important.
Finding Power - Divinations - Every
The way to solve the problem is to control the layers of the value chain where the problems arise, and integrate them together in a new way that makes things better for buyers.
Finding Power - Divinations - Every
This isn’t to say that if you say you care about community, you must live in a co-op. Rather, I bring this up to show that we derive meaning from the doing. We often think that we should invest in activities only if we find them meaningful, but I believe the causal relationship more often goes the other way: we find activities meaningful through our investment in them.
Against Ikigai - Superorganizers - Every
Second, prioritize and focus. Think of your business like an equation, and study each step in the process to see which you think could be most improved and would have the biggest impact if improved. For example, with Every right now I think the single biggest thing I can do is just to write better.
Execution is Exponential - Divinations - Every
This is why investors often bias towards people that have worked in hyper-growth startups in the past. If you don’t know what “good” looks like, you will have a hard time replicating it and might prematurely conclude you have a bad plan when actually you just didn’t execute it well enough.
Execution is Exponential - Divinations - Every
good execution in one area tends to lead to good execution in other areas of the business, because good execution is only possible within a culture that permits (and even demands) excellence.
Execution is Exponential - Divinations - Every
And the most important fork in that tree is to classify the situation as a “strategy problem” or an “execution problem.” In other words, do we need to do a better job of executing our current plan? Or do we need a new plan?
Execution is Exponential - Divinations - Every
If your entire conscious existence was spent in an office where the only reading material you had access to was the employee handbook, you’d think it was amazing too!
DALL·E 2 and The Origin of Vibe Shifts - Divinations - Every
Now that we have DALL·E 2 (and other AI image generators), a huge portion of visual vibes will become democratized. What Unsplash did to photography, DALL·E 2 will do to illustrations, 3D renderings, and eventually all visual styles.
DALL·E 2 and The Origin of Vibe Shifts - Divinations - Every
In the words of psychologist Rollo May, “Commitment is healthiest when it is not without doubt, but in spite of doubt.”
Dealing with Doubt on the Pathless Path - Every
I’ll be the first to say that your colleagues aren’t your family, but they are people who know and validate you. They’re people with whom to banter and ask out to lunch. It’s scary not to have a consistent group of people to depend on who depend on me.
Dealing with Doubt on the Pathless Path - Every
Whatever your safety behaviors are it’s crucial that you identify them because in order for exposure to work you need to stop doing them in the presence of the thing you fear
Fear, Courage, and Willingness - Superorganizers - Every