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Carbon-negative production of acetone and isopropanol by gas fermentation at industrial pilot scale | Nature Biotechnology

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Two industrial chemicals are sustainably produced at large scale by microbial gas fermentation.

Subjects Metabolic engineering Synthetic biology An Addendum to this article was published on 21 July 2025 Abstract Many industrial chemicals that are produced from fossil resources could be manufactured more sustainably through fermentation. Here we describe the development of a carbon-negative fermentation route to producing the industrially important chemicals acetone and isopropanol from abundant, low-cost waste gas feedstocks, such as industrial emissions and syngas. Using a combinatorial pathway library approach, we first mined a historical industrial strain collection for superior enzym

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