Neurocircuitry of Addiction - PMC

Drug addiction is a chronically relapsing disorder that has been characterized by (1) compulsion to seek and take the drug, (2) loss of control in limiting intake, and (3) emergence of a negative emotional state (eg, dysphoria, anxiety, irritability) ...

Neuropsychopharmacology . 2009 Aug 26;35(1):217–238. doi: 10.1038/npp.2009.110 Neurocircuitry of Addiction George F Koob George F Koob 1 Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA, USA Find articles by George F Koob 1, * , Nora D Volkow Nora D Volkow 2 National Institute on Drug Abuse, Bethesda, MD, USA Find articles by Nora D Volkow 2 Author information Article notes Copyright and License information 1 Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA, USA 2 National Institute on Drug Abus

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