MHC class I
MHC class I molecules are one of two primary classes of major histocompatibility complex (MHC) molecules (the other being MHC class II) and are found on the cell surface of all nucleated cells in the bodies of vertebrates. They also occur on platelets, but not on red blood cells. Their function is to display peptide fragments of proteins from within the cell to cytotoxic T cells; this will trigger an immediate response from the immune system against a particular non-self antigen displayed with the help of an MHC class I protein. Because MHC class I molecules present peptides derived from cytosolic proteins, the pathway of MHC class I presentation is often called cytosolic or endogenous pathway.
MHC class I Schematic representation of MHC class I Identifiers SymbolMHC class I Membranome63 MHC class I molecules are one of two primary classes of major histocompatibility complex (MHC) molecules (the other being MHC class II) and are found on the cell surface of all nucleated cells in the bodies of vertebrates.[1][2] They also occur on platelets, but not on red blood cells. Their function is to display peptide fragments of proteins from within the cell to cytotoxic T cells; this will trigger an immediate response from the immune system against a particular non-self antigen…
saved by
related reading
- Cross-presentation - Wikipediaen.wikipedia.org
- Mesa — JURA Bio, Inc.jura.bio
- Lymphocytes and the Cellular Basis of Adaptive Immunity - Molecular Biology of the Cell - NCBI Bookshelfncbi.nlm.nih.gov
- Macrophage - Wikipediaen.wikipedia.org
- Mechanisms of Immunosuppression - Holland-Frei Cancer Medicine - NCBI Bookshelfncbi.nlm.nih.gov
- Lysosome-targeting chimaeras for degradation of extracellular proteins | Naturenature.com
- The T Cell Marker, CD3 Antigen & Antibodies: Mini-review | Bio-Radbio-rad-antibodies.com
- Receptor mediated uptake of peptides that bind the human transferrin receptor - PubMedpubmed.ncbi.nlm.nih.gov
- jsomers.net | I should have loved biologyjsomers.net
- T cell receptors overview - Mini-review | Bio-Radbio-rad-antibodies.com
- Enteromeenterome.com
- Immune Regulation | People | Osaka University Immunology Frontier Research Centerifrec.osaka-u.ac.jp