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Overview of the treatment of newly diagnosed, invasive, non-metastatic breast cancer - UpToDate

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Improvements in breast cancer screening and treatments are decreasing breast cancer mortality. In a study using four simulation models of breast cancer mortality rates in the United States (US), breast cancer screening and treatment in 2019 were associated with a 58 percent reduction in US breast cancer mortality compared with 1975 [1]. Approximately half of this reduction was due to treatment of early breast cancer, while the rest was divided roughly equally between treatment of metastatic breast cancer and breast cancer screening. We support breast cancer screening for appropriate candidates and incorporate novel, data-driven strategies into our treatment recommendations for breast cancer. (See "Overview of the treatment of newly diagnosed, invasive, non-metastatic breast cancer", section on 'Introduction' and "Screening for breast cancer: Strategies and recommendations".) Read more INTRODUCTION In the United States, breast cancer is the most commonly diagnosed non-skin cancer and th

Overview of the treatment of newly diagnosed, invasive, non-metastatic breast cancer INTRODUCTION In the United States, breast cancer is the most commonly diagnosed non-skin cancer and the second most common cause of cancer death in females [1]. Breast cancer is treated with a multidisciplinary approach involving surgical oncology, radiation oncology, and medical oncology, which has been associated with a reduction in breast cancer mortality [2,3]. This topic will provide an overview of the initial treatment of breast cancer. Our approach is generally consistent with expert guidelines…

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